The Giga Mouse Universal Genotyping Array (GigaMUGA) provides more than 143,000 SNP markers built on the Illumina Infinium platform. The GigaMUGA improves upon the 78,000 SNP MegaMUGA and includes nearly all of the predecessor’s content. A majority of the SNP markers are distributed throughout the mouse genome and were selected to be informative in most mouse populations, including wild mice and multiple Mus species, but with a special emphasis for markers that are informative in the Collaborative Cross and Diversity Outbred population resources. The utilization of these informative SNPs make the array a highly cost-effective tool for many genotyping applications. The GigaMUGA design criteria make it optimal for detecting heterozygous regions and discriminating between haplotypes in homozygous regions.
The GigaMUGA includes an excess of probes in the telomeric regions of each autosome to facilitate detection of recombination events throughout the chromosome. More than 46,000 SNPs were specifically selected to flank a catalog of more than 20,000 recombination hotspots. The array also includes more than 2000 non-SNP probes intended for exploring copy number variation in regions selected from previously published data.
*GigaMUGA content and design were done at the University of North Carolina at Chapel Hill under the supervision of Fernando Pardo-Manuel de Villena and Leonard McMillan.